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dc.contributor.authorSouza, Marina de Assis
dc.contributor.authorCastro, Maria C. A. Brelaz de
dc.contributor.authorOliveira, Andresa Pereira de
dc.contributor.authorAlmeida, Amanda Ferreira de
dc.contributor.authorAlmeida, Thays Miranda de
dc.contributor.authorReis, Luiza C.
dc.contributor.authorMedeiros, Angela Cristina Rapela
dc.contributor.authorBrito, Maria Edileuza Felinto de
dc.contributor.authorPereira, Valeria Rego Alves
dc.date.accessioned2024-10-21T18:46:44Z
dc.date.available2024-10-21T18:46:44Z
dc.date.issued2013
dc.identifier.citationMicrob. Pathog.
dc.identifier.urihttp://dx.doi.org/10.1016/j.micpath.2013.02.004
dc.identifier.urihttps://repositorio.maua.br/handle/MAUA/1497
dc.description.abstractStudies suggest the influence of immune response on the successful treatment of American tegumentary leishmaniasis (ATL), and indicate the existence of protective immunity in self-healed patients. Thus, the aim of this work was to quantify interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL-) 10, IL-17, IL-22 and nitric oxide (NO) in culture supernatants of PBMC from patients with active disease (AD), after treatment (AT), and from self-healed (SH) and healthy subjects (CT), in response to Leishmania (Viannia) braziliensis insoluble antigen (AgIns). All groups of patients produced IFN-gamma, indicating a predominant proinflammatory profile. AD and AT patients presented TNF-alpha levels, with a slight increase after therapy, whereas it was weakly quantified in SH. Interestingly, NO secretion was significant in these individuals, whereas IL-17 appeared in low levels and seems to be regulated by NO. Although IL-22 was detected in AD, its role is still questionable. The presence of IL-10 in all groups of patients suggests that the cytokine plays distinct roles in the disease. These results indicate that specific cellular immunity takes part against Leishmania, but with some similarities between the different clinical states herein described; these mediators seem to be necessary for the cure to occur. (C) 2013 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipCAPES(Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES))pt_BR
dc.description.sponsorshipCNPq(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ))pt_BR
dc.description.sponsorshipFIOCRUZpt_BR
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipFIOCRUZ
dc.format.extent6.0
dc.languageInglêspt_BR
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDen
dc.relation.ispartofMICROBIAL PATHOGENESIS
dc.rightsAcesso Aberto
dc.sourceWeb of Scienceen
dc.subjectCytokinesen
dc.subjectCellular immunityen
dc.subjectLeishmania braziliensisen
dc.subjectLeishmaniasisen
dc.subjectNitric oxideen
dc.subjectCUTANEOUS LEISHMANIASISen
dc.subjectMUCOSAL LEISHMANIASISen
dc.subjectNITRIC-OXIDEen
dc.subjectIMMUNE-RESPONSESen
dc.subjectCLINICAL CUREen
dc.subjectMECHANISMSen
dc.subjectBRAZILIENSISen
dc.subjectCHEMOTHERAPYen
dc.subjectPARASITESen
dc.subjectGENESen
dc.subjectImmunologyen
dc.subjectMicrobiologyen
dc.subject.otherCytokinesen
dc.subject.otherCellular immunityen
dc.subject.otherLeishmania braziliensisen
dc.subject.otherLeishmaniasisen
dc.subject.otherNitric oxideen
dc.subject.otherCUTANEOUS LEISHMANIASISen
dc.subject.otherMUCOSAL LEISHMANIASISen
dc.subject.otherNITRIC-OXIDEen
dc.subject.otherIMMUNE-RESPONSESen
dc.subject.otherCLINICAL CUREen
dc.subject.otherMECHANISMSen
dc.subject.otherBRAZILIENSISen
dc.subject.otherCHEMOTHERAPYen
dc.subject.otherPARASITESen
dc.subject.otherGENESen
dc.subject.otherImmunologyen
dc.subject.otherMicrobiologyen
dc.titleCytokines and NO in American tegumentary leishmaniasis patients: Profiles in active disease, after therapy and in self-healed individualsen
dc.typeArtigo de Periódicopt_BR
dc.identifier.doi10.1016/j.micpath.2013.02.004
dc.description.affiliationFundacao Oswaldo Cruz
dc.description.affiliationUniversidade de Sao Paulo
dc.description.affiliationInstituto Maua de Tecnologia
dc.description.affiliationUniversidade Federal de Pernambuco
dc.identifier.wosWOS:000316921400005
dc.contributor.orcidReis, Luiza Campos/0000-0001-5412-4066
dc.contributor.orcidAlves Pereira, Valeria Rego/0000-0002-7995-7360
dc.contributor.orcidCastro, Maria Carolina/0000-0003-2205-0618
dc.contributor.orcidDe Assis Souza, Marina/0000-0003-2540-3706
dc.citation.epage32
dc.citation.spage27
dc.citation.volume57


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