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dc.contributor.authorAlbanez, Roberta
dc.contributor.authorNitz, Marcello
dc.contributor.authorTaranto, Osvaldir Pereira
dc.date.accessioned2024-10-15T21:10:52Z
dc.date.available2024-10-15T21:10:52Z
dc.date.issued2013
dc.identifier.issn1568-5527
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84876978143&doi=10.1016%2fj.apt.2012.12.003&partnerID=40&md5=9c39ec2e23d2e1a075460b80393d56f7
dc.identifier.urihttps://repositorio.maua.br/handle/MAUA/1246
dc.description.abstractThe objective of this work was to study the coating process of diclofenac sodium pellets, with the commercial aqueous coating suspension for enteric release-Acryl-Eze® MP, in a fluid bed coater with a Wurster insert. Coating experiments were performed following a 22 factorial design to determine the influence of process variables on coating performance, measured by the two response variables: efficiency (η%) and agglomeration index (magg%). Both response variables were found to be affected by inlet temperature and suspension flow rate with a 95% confidence level. This work also studied the release of diclofenac sodium coated and uncoated pellets in HCl 0.1 N and pH 6.8 phosphate buffer media. Results showed that the release of diclofenac sodium during the buffer stage was affected by the prior exposure to the HCl 0.1 N medium and a polymer weight gain above 9.7% (2.7 mg/cm 2), was needed to modify the release in such a way that it remained below 10% for the first 120 min in HCl 0.1 N and above 75% in pH 6.8 for the next 45 min. Neither the drug content nor the release profiles were significantly affected by storage at 40 °C and 75% relative humidity. © 2013 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.en
dc.description.sponsorshipFAPESP
dc.languageInglêspt_BR
dc.relation.ispartofAdvanced Powder Technology
dc.rightsAcesso Restrito
dc.sourceScopusen
dc.subjectCoatingen
dc.subjectDiclofenac sodiumen
dc.subjectFluidized beden
dc.subjectGastro-resistanceen
dc.subjectPelletsen
dc.subjectFluidized bedsen
dc.subjectOre pelletsen
dc.subjectPelletizingen
dc.subjectSodiumen
dc.subjectSuspensions (fluids)en
dc.subjectCoating performanceen
dc.subjectConfidence levelsen
dc.subjectFactorial designen
dc.subjectInlet temperatureen
dc.subjectPhosphate buffersen
dc.subjectProcess Variablesen
dc.subjectCoatingsen
dc.titleEnteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profileen
dc.typeArtigo de Periódicopt_BR
dc.identifier.doi10.1016/j.apt.2012.12.003
dc.description.affiliationMauá Institute of Technology (IMT), São Caetano Do sul, 09580-900, São Caetano do Sul-SP, Praça Mauá, 1, Brazil
dc.description.affiliationSchool of Chemical Engineering, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
dc.identifier.scopus2-s2.0-84876978143
dc.citation.issue3
dc.citation.epage666
dc.citation.spage659
dc.citation.volume24


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