dc.contributor.author | Albanez, Roberta | |
dc.contributor.author | Nitz, Marcello | |
dc.contributor.author | Taranto, Osvaldir Pereira | |
dc.date.accessioned | 2024-10-15T21:10:52Z | |
dc.date.available | 2024-10-15T21:10:52Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1568-5527 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876978143&doi=10.1016%2fj.apt.2012.12.003&partnerID=40&md5=9c39ec2e23d2e1a075460b80393d56f7 | |
dc.identifier.uri | https://repositorio.maua.br/handle/MAUA/1246 | |
dc.description.abstract | The objective of this work was to study the coating process of diclofenac sodium pellets, with the commercial aqueous coating suspension for enteric release-Acryl-Eze® MP, in a fluid bed coater with a Wurster insert. Coating experiments were performed following a 22 factorial design to determine the influence of process variables on coating performance, measured by the two response variables: efficiency (η%) and agglomeration index (magg%). Both response variables were found to be affected by inlet temperature and suspension flow rate with a 95% confidence level. This work also studied the release of diclofenac sodium coated and uncoated pellets in HCl 0.1 N and pH 6.8 phosphate buffer media. Results showed that the release of diclofenac sodium during the buffer stage was affected by the prior exposure to the HCl 0.1 N medium and a polymer weight gain above 9.7% (2.7 mg/cm 2), was needed to modify the release in such a way that it remained below 10% for the first 120 min in HCl 0.1 N and above 75% in pH 6.8 for the next 45 min. Neither the drug content nor the release profiles were significantly affected by storage at 40 °C and 75% relative humidity. © 2013 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved. | en |
dc.description.sponsorship | FAPESP | |
dc.language | Inglês | pt_BR |
dc.relation.ispartof | Advanced Powder Technology | |
dc.rights | Acesso Restrito | |
dc.source | Scopus | en |
dc.subject | Coating | en |
dc.subject | Diclofenac sodium | en |
dc.subject | Fluidized bed | en |
dc.subject | Gastro-resistance | en |
dc.subject | Pellets | en |
dc.subject | Fluidized beds | en |
dc.subject | Ore pellets | en |
dc.subject | Pelletizing | en |
dc.subject | Sodium | en |
dc.subject | Suspensions (fluids) | en |
dc.subject | Coating performance | en |
dc.subject | Confidence levels | en |
dc.subject | Factorial design | en |
dc.subject | Inlet temperature | en |
dc.subject | Phosphate buffers | en |
dc.subject | Process Variables | en |
dc.subject | Coatings | en |
dc.title | Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile | en |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.doi | 10.1016/j.apt.2012.12.003 | |
dc.description.affiliation | Mauá Institute of Technology (IMT), São Caetano Do sul, 09580-900, São Caetano do Sul-SP, Praça Mauá, 1, Brazil | |
dc.description.affiliation | School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil | |
dc.identifier.scopus | 2-s2.0-84876978143 | |
dc.citation.issue | 3 | |
dc.citation.epage | 666 | |
dc.citation.spage | 659 | |
dc.citation.volume | 24 | |