Kinetic resolution of α-bromophenylacetamides using quinine or Cinchona alkaloid salts

xmlui.dri2xhtml.METS-1.0.item-type
Date
2012
Author
xmlui.dri2xhtml.METS-1.0.item-sponsorship
Metadata
Show full item record
Abstract
The kinetic resolution of racemic α-bromophenylacetamides 1 was achieved in the presence of benzenethiolate and Cinchona alkaloid salts as phase-transfer catalysts or benzenethiol and quinine, yielding (S)-enantioenriched α-sulfanylated products. The observed stereoselection was rationalized on the basis of the best fitting of 1 and the resolving agent in the ternary complexes. © 2012 Elsevier Ltd. All rights reserved.
  1. alpha bromophenylacetamide derivative
  2. Cinchona alkaloid
  3. quinine
  4. thiophenol
  5. unclassified drug
  6. article
  7. catalyst
  8. kinetics
  9. priority journal
  10. reaction analysis
  11. stereochemistry
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862985015&doi=10.1016%2fj.tetasy.2012.05.009&partnerID=40&md5=53026e159d86da1129aa3d9fb00feeb5
https://repositorio.maua.br/handle/MAUA/1241
Collections