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dc.contributor.authorBessa, K.L.
dc.contributor.authorBelletati, J.F.
dc.contributor.authordos Santos, L.
dc.contributor.authorRossoni, L.V.
dc.contributor.authorOrtiz, J.P.
dc.date.accessioned2024-10-15T21:08:35Z
dc.date.available2024-10-15T21:08:35Z
dc.date.issued2011
dc.identifier.issn0100-879X
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84860409958&doi=10.1590%2fS0100-879X2011007500071&partnerID=40&md5=fd1f63cb91e45f292b660c441c12c566
dc.identifier.urihttps://repositorio.maua.br/handle/MAUA/1238
dc.description.abstractThis study was designed to evaluate the effect of drag reducer polymers (DRP) on arteries from normotensive (Wistar) and spontaneously hypertensive rats (SHR). Polyethylene glycol (PEG 4000 at 5000 ppm) was perfused in the tail arterial bed with (E+) and without endothelium (E-) from male, adult Wistar (N = 14) and SHR (N = 13) animals under basal conditions (constant flow at 2.5 mL/min). In these preparations, flow-pressure curves (1.5 to 10 mL/min) were constructed before and 1 h after PEG 4000 perfusion. Afterwards, the tail arterial bed was fixed and the internal diameters of the arteries were then measured by microscopy and drag reduction was assessed based on the values of wall shear stress (WSS) by computational simulation. In Wistar and SHR groups, perfusion of PEG 4000 significantly reduced pulsatile pressure (Wistar/E+: 17.5 ± 2.8; SHR/E+: 16.3 ± 2.7%), WSS (Wistar/E+: 36; SHR/E+: 40%) and the flow-pressure response. The E- reduced the effects of PEG 4000 on arteries from both groups, suggesting that endothelial damage decreased the effect of PEG 4000 as a DRP. Moreover, the effects of PEG 4000 were more pronounced in the tail arterial bed from SHR compared to Wistar rats. In conclusion, these data demonstrated for the first time that PEG 4000 was more effective in reducing the pressure-flow response as well as WSS in the tail arterial bed of hypertensive than of normotensive rats and these effects were amplified by, but not dependent on, endothelial integrity. Thus, these results show an additional mechanism of action of this polymer besides its mechanical effect through the release and/or bioavailability of endothelial factors.en
dc.languageInglêspt_BR
dc.publisherAssociacao Brasileira de Divulgacao Cientificaen
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.sourceScopusen
dc.subjectDrag reductionen
dc.subjectEndotheliumen
dc.subjectFlow-pressure responseen
dc.subjectHypertensionen
dc.subjectPolyethylene glycolen
dc.subjectShear stressen
dc.subjectAnimaliaen
dc.subjectRattusen
dc.subjectRattus norvegicusen
dc.subjectbiological factoren
dc.subjectdrag reducing polymeren
dc.subjectmacrogol 4000en
dc.subjectpolymeren
dc.subjectunclassified drugen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectartery blood flowen
dc.subjectartery diameteren
dc.subjectartery endotheliumen
dc.subjectartery wallen
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectdrag reductionen
dc.subjectdrug effecten
dc.subjectdrug mechanismen
dc.subjectendothelial dysfunctionen
dc.subjectfrictionen
dc.subjecthypertensionen
dc.subjectmaleen
dc.subjectmechanicsen
dc.subjectnonhumanen
dc.subjectraten
dc.subjectshear stressen
dc.subjectsimulationen
dc.subjecttailen
dc.subjecttreatment outcomeen
dc.subjectviscosityen
dc.titleDrag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive ratsen
dc.typeArtigo de Periódicopt_BR
dc.identifier.doi10.1590/S0100-879X2011007500071
dc.description.affiliationDepartamento de Ciências Ambientais e Tecnológicas, Universidade Federal Rural do Semi-Árido, Mossoró, RN, Brazil
dc.description.affiliationDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
dc.description.affiliationDepartamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil
dc.description.affiliationDepartamento de Engenharia Mecânica, Escola Politécnica, Universidade de São Paulo, São Paulo, SP, Brazil
dc.description.affiliationInstituto Mauá de Tecnologia, Escola de Engenharia, São Caetano do Sul, SP, Brazil
dc.identifier.scopus2-s2.0-84860409958
dc.citation.issue8
dc.citation.epage777
dc.citation.spage767
dc.citation.volume44


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